The aim of the present work was to prepare and evaluate osmotic controlled drug delivery system of Cyproheptadine hydrochloride that can provide continuous drug release for period of 24 hours. Different formulations were made using different osmotic agent like Kcl, mannitol, Fructose and mannose. SLS used as wicking agent and OPADRY CA was used as a semi permeable coating membrane which is co process excipient of cellulose acetate and PEG 6000(9:1). The tablets were subjected to thickness, hardness, friability, weight variations, and drug content by assay and in vitro dissolution studies. Drug release was observed in different pH media and different agitation study and was observed that batch containing Kcl shows sustain delivery of the drug for 24 hr with zero order release. And also drug release was independent from pH media and agitation intensity.
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